Well, I had my first "problem" with the 2020 Python yesterday. At one point it skipped advancing the cylinder and the hammer fell on an already fired cartridge. A brief stop and it continued to function in dry fire mode, so I went back to shooting. In a couple of cylinders, it did the same thing.
This time I stopped and looked things over closely and found that the two screws on the left side of the gun were loose. If you look at the pictures I posted earlier, of the left side, you'll see a screw about middle of the trigger guard, and there is another under the grips that you can't see. The one in the middle of the trigger guard was so loose, the sideplate was starting to come up. Since the sideplate is used to hold all the internals in place that was allowing them to come out of alignment with each other. (This is as I understand it from what people who know a lot more about the internals tell me. I ain't that smart.)
It took about thirty seconds to find a screwdriver in my bag, a minute to remove the grips, and a few more seconds to snug each screw down, and flip the gun over and check the one on the right side. It was OK.
I had 450 or so rounds through it at this point, almost all of them being 357 Magnums. After I tightened up the screws, I went back to shooting with no more problems and have dry fired it another hundred or so times. I'm sure that was, and has resolved the "problem." I have purple locktite on order and will put a dab on those screws when it arrives.
So, other than that, I'm up to 500 rounds with no real problems. No, I don't consider having to snug a screw to be a "problem."