I've got three of the 2020 Pythons so it's fair to say I like them. One 6", and two 4.2" ones. I'd have been happy with just the two, but my wife wanted one of her own, so I suppose technically I have three of them in my safe.
If there is a difference between the 6" and the 4" in the way they shoot, I sure can't tell it, but I freely admit that I'm not a great shot in the first place. Personally I like 4" barrel revolvers. I only bought the 6" one because it was the first one I saw. The S/N is in the < 3000 range so it's out of the first "batch." No problems with the gun at all, other than having to tighten up the sideplate screws one time. They haven't come loose again. The two 4" guns, from later production have been trouble free.
The cylinders are short. I had to seat 158 grain bullets a little deeper into 357 cases than I was used to with my Smith and Wesson's. Something I'd never encountered before, but I usually shoot 38 Special's due to having a bucket full of 38 brass. No factory ammo has been a problem.
A lot of people complain about the grips. They don't like the "plywood" look I suppose. Personally, I like the muted look against the bright metal, and I think they among the most comfortable grips I've ever used, at least factory grips. That will differ from one person to another, but I never cared for the "target" grips on the older Colts. They had a lot of flair at the base of the grip making my little finger all but useless, and the checkering, although beautiful to look at, made shooting the gun feel like holding onto a wood rasp, especially with hard recoiling loads. These new ones don't have either problem for me.
The triggers out of the box are at least to my mind very good. No stacking just a smooth pull through. They beg to be fired DA. Normally I do a lot of my shooting in S/A, but I don't think I've fired either of the three in SA since the first time out with the 6" gun. Once I tried the DA, I just never looked back.
My favorite load in all three is a 148 HB Berry's wadcutter, over the normal load of Bullseye. That one just cuts nice clean holes in the target, very close together. 125 and 158 grain Berry's have also performed well at various loads in both 38 and 357 loadings.
If there is anything I don't like it's the rear sight. It works fine, but requires a small Allen head wrench, not supplied, to make adjustments. Loosen the set screw, adjust as normal with two different sized screwdrivers, tighten the set screw. I'm sure that could be simplified.
I've probably got about 1000 rounds through the three. Most of them (800 rounds) in the 6" gun but that's the first one I got. The first 4" gun I got right as the COVID hit, so it sat for a long time unfired. The third one I got a few weeks ago. It's been to the range once along with revolver #2. I've split the remaining 200 rounds between those two. I need to shoot them all more I know.
Since we all like pictures, and I like to show off...my apologies for the poor lighting. The other 4" one looks just like this one. I have to check the S/N to know which is which.