My primary is a 1911, . . . a .380 Bersa Thunder is the backup, . . . and my son's Browning Buckmark .22 rounds out the trio I would feel comfortable carrying under most circumstances.
My greatest reluctance to the .22 rests only in the "ignition" question, as just about all the "today" .22 rounds seem to have too many duds in the box.
That said, however, . . . if the other two were not available, . . . the Browning is in my mind a solid choice, . . . carrying a spare mag.
When I practice with the 1911, . . . all shots are COM, . . . .380 and .22 are all head shots, . . . center of the pumpkin.
May God bless,
Dwight