I've related this story a couple times, but here it is again...
MRS. cousin was deer hunting over by the Mississippi river & hit a big buck at about 30 yards, with a 12 ga slug... slug hit a rib going in, slug & shattered bone, took out both lungs, with an exit wound nearly the size of a volley ball on the other side... blood spewed everywhere, yet the buck jumped, & ran almost a 1/2 mile up an at least 45* bluff hill, before it fell over completely drained of blood
the ONLY guarantied one shot DRT kill, hits the CNS...
so shot placement, with a cartridge with enough power to hit the CNS is the only sure bet...
after that... yep they die... just how long, how much meat damage...
again another old story I've told many times...
when I was 1st dating ( my now long time wife ) I was the newbie at FIL's deer camp... I think just to make sure I knew how, for several years I was privileged to field dressing all the deer shot... rifles ranged from a .243, several 30-06's, a 300 Win Mag, & a 45-70... everyone was good shots, & we rarely tracked deer... surprisingly the 45-70 often had less blood shot ( bruising ) around the wound track, the .243 & 30-06's had about the same, & the 300 Win Mag had over an inch more radially...
after a couple years, I became a big fan of the 45-70, & less of a fan of the hyper velocity stuff, for anything more than explosive varmint use... but no matter what you're using, you must have a good hit, & the tracking distance can vary greatly, unless you get a CNS hit