The DNC side of the house has been openly talking about nuking the filibuster.
They already did. Harry Reid did so in 2013 in order to get vacancies filled quickly in the federal courts. He made a pinky-swear that this would never, ever apply to Supreme Court appointments, though. Lindsey Graham and Mitch McConnell were among the Senators who warned him not to do it.
From there, it was a short jump. Now it only takes 51 votes to break a filibuster, and it only takes 51 votes to confirm. That means the party with the bare majority in the Senate gets to make the appointment.
Republicans currently hold 53 seats (54 if we count VP Pence as a tie-breaker). Even with a couple of defections, they can get what they want.