Reloaders occasionally run into large discrepancies in load data, as in this case. The reason(s) for the discrepancies are seldom known for certain since the testing sites and equipment are usually different, as well as some of the reloading components.
In this case I see two significant differences which may explain the discrepancy. First, the Lyman data is based on crusher test results, for which there is no established SAAMI standard. Hornady likely used PSI results to establish their published reloading data. Speer doesn't make a lighter 45 caliber bullet suitable for full power Casull loads, but their 300gr bullet is. Speer and Hornady reloading data for their 300gr bullets correlates well.
Second, Lyman used small rifle magnum primers, whereas Hornady used standard small rifle primers. Magnum primers often raise pressure significantly, especially with some powders in certain cartridges. Of the five reloading data sources I checked for the 454 Casull, only Lyman used magnum primers.
If I was using the 240gr XTP MAG, I would use the primer specified in the Hornady manual and begin with their starting load and work up from there, loading only 5 or 10 rounds at each charge level.