For me, its not about the ultimate strength of the gun as much as what I want, and what I am used to. Especially the "what I am used to", these days.
Got my first Ruger (new model) Blackhawk in .45 Colt/,45ACP in 1983. And, while I had read a lot about SA revolvers over the years, I had never had one before. It was a wonderful, eye-opening experience.
I got the gun because of the .45ACP cylinder. I had a .45 auto, and figured this gun would let me plink with my ACP ammo without having to chase and hunt for my brass. I picked up the gun and started home with it, and realized that I did not have any .45 Colt ammo for it, just ACP, so I stopped at a store on the way home and bought a box. Winchester 255gr the standard load.
I learned how my new model was different from the Colt SAA, that was kinda neat, could safely carry 6, not 5, and not having to put the gun on half cock (there isn't a half cock position) to load and unload was cool, too. And adjustable sights was a huge plus over the Colt SAA.
I made one small "mistake", the first time I shot the gun was with .45 Colt ammo. WOW!!
The gun roared, the muzzle rose to the sky and I was hooked. After that, shooting ACP ammo in that gun was ...:meh"... ACP goes bang and the gun recoils enough that you know it went off, but nothing like what it does with even "regular" .45 Colt loads.
Since I had a great article in the Handloader Digest about loading the Ruger .45 Colt (there was only one at the time) of course, I tried out the heavy loads all the way up to the "Ruger Only" loads.
Learned that shooting heavy loads hurt my middle finger. Learned that Pachmayr grips prevented that, and gave me more to hang on to. Gun still rolls in the hand, just not as much. Also learned that the really heave loads are not pleasant to shoot, even with Pachmayr grips. Just not fun after a few rounds. With slightly heavier than standard factory ammo its fun and I can shoot all day if I want, without injury or serious fatigue.
So that gun got me hooked on the .45 Colt, since then, that gun has had thousands of rounds of .45 Colt fired through it, and only about 300 rnds of ACP I also have several Vaqueros in .45 Colt. And, I did have a New Vaquero, also in .45 Colt.
The New Vaquero was a nice gun, but it just never felt "right". Its was smaller (Colt size) than what I was used to, and after 30+ years shooting the larger Blackhawks and Vaqueros, it just seemed "small".
Because, of course, it is. A 4 5/8" barrel Vaquero and a 5.5" barrel New Vaquero are almost exactly the same size!! I don't mean the cylinders or frames, I mean overall size. Butt to muzzle the length is damn near the same (might be a small difference but not enough to see)
IF a Colt size gun is what you want, get a New Vaquero. I've got decades shooting the large frame Blackhawks, love them and have no real interest in the smaller guns, including the Flattops.
The alloy parts don't bother me, nor does the fact that the cylinder doesn't "stop" with the chamber perfectly centered in the loading gate.
About 30 some years ago I settled on one load, a 250gr swc on top of 10gr Unique. This is a heavy load in the old books and SAFE in COLT guns, so its nothing stressful in ANY of the Rugers. Does about 1100fps from my 7.5" and a bit less from shorter barrels. Powerful, fun to shoot, accurate in my guns (and in my hands!) if I want something more, I could load it, or simply go to a different caliber (.44mag for one).
The big Blackhawks are great guns, and for me, after nearly 40 years of using them, nothing else seems quite "right".
Nothing "wrong" with the smaller guns, just not "right" to me.
YMMV