I am use to wearing a radio on my strong side at work. So, I am use to the lopsided feeling. It doesn't feel that weird to me. I don't have the strong side swing or shuffle.
I do feel a little raw if I don't wear an undershirt. The CZ P-07 has agressive grip texturing similar to skateboard grip tape. So, after a few hours it rubs a red patch on my side. I've taken to wearing undershirts tucked in. So, I guess you could say carrying makes me a little warmer than usual.
I was nervous at first that I would get spotted or show. A good IWB holster solved that problem. I can carry a "compact" CZ with out the slightest print with a good IWB. It didn't even require going up a size in shirts. After about three or four days I started feeling like it was normal as pie.