Ignore her at your peril
Have had several experiences over the years buying guns with the idea that they would work for my wife.
Bottom line: if she's not motivated to become a shooter for the fun of it, then you're going to have to keep it simple--she won't practice all the safeties, magazine releases, etc. Therefore, revolver becomes the choice because it's simple & much safer to use with minimal training. (Both are very safe with practice.)
You also MUST get something that fits her hand. My wife has small hands & can't reliably handle a S&W K-frame, but does great with the J-frame. Also the older Colt D-frames (by the bed she has a Police Positive .38SPL 4" bbl, and in the car a 2" Detective Special--same ammo, same action, just different barrels). Accuracy not a problem at 5-7 yards for her; even though she only shoots about once a year at best, it's typically a hand-sized group in rapid fire.
Plus-P ammo is great if your wife can handle it, but it may create more blast/flash than she wants. That's almost a certainty with airweight models, but less likely with steel. The airweights fit my wife & teenage daughters great, but the muzzle flip & recoil almost spoiled shooting for them. I recommend wadcutter target ammo first, and move up from there if your wife likes it OK. Settle on what you both like & can find available in stores.
By the way, the Ruger SP-101s fit all of my gals great, and they like them fine. I do, too. We have two.
If car and/or purse or concealed carry are likely, look at 2-3" barrels. If home only, 3"-4" probably would be best.
Now, after you & your wife get some practice, you may decide to open up other options. Yes, some women shoot autos, .44 Mags & 12 gauge shotguns, IF they become aficionados. Few go for those options unless they become avid shooters, as best I can tell. My wife found even the recoil/muzzle flip of a .380 Beretta unpleasant to shoot, and it's not as powerful as most .38SPL loads. My very petite 19-year-old daughter prefers a S&W .32 snubbie due to small size and LOW recoil; my 13-year-old prefers a .38 and does fine with all of ours.
Get what you can handle & get ammo for, choose a reputable brand of gun & ammo, and practice as much as possible. And remember that something is better than nothing, as long as you & she have the will to use it.