Is home defense semi-auto the same as night-stand semi-auto? If it is forget any Glock pistol's. Glock's are okay for WIDE-AWAKE home defense but not tucked away as you're countin' sheep.
You wake up in a stupper (you know the feeling, half awake, not fully alert) and you grab your Glock with a 51/2lb trigger. First round goes through the floor, the second through the mirror, and if you're still alive the third somewhere toward the intruder.
For a night-stand gun you want something you have to consciously manipulate (ie pump shotgun, "flick" off safety of 1911 or Beretta, long trigger of revolver or semi-auto).
As for myself? A P-220. My buddy has a USP 45 with a Tac-Lite. Just My Thoughts, J. Parker