Evil Monkey said:
See these major blood vessels? If you're not hitting these, you are not rapidly incapacitating anybody, unless they choose to give up the fight or get shot in the head/neck. Got nothing to do with guts, liver, kidneys, smaller capillaries, etc, none of those regions are as efficient as striking the big vessels.
In a self-defense situation, you don't want to incapacitate your opponent, you want to STOP him -- before he can stop you.
Except for shots to the heart, most of the shots to the major blood vessels won't
RAPIDLY incapacitate the person shot. Even a direct shot to the heart isn't necessarily a fast stop -- it can take up to minute in some cases for him to drop -- and that gives the other guy time to KILL you before he drops.
A shot to the head, or a shot to the spine, high or low, can stop things almost instantly. All of the above is even better. And doing it with a low-recoil, high capacity weapon may make it easier.
If you read about the infamous FBI shootout in Miami back in the 80's, the two bad guys were hit by a a number incapacitating shots, and those shots would have caused them to eventually bleed out -- but they killed two FBI agents and wound several others before that happened. They were finally stopped by several CNS shots from one agent.
Temporary or permanent wound cavities might be debilitating, but they won't always debilitate quickly if at all -- particularly if the target is experienced, determined to get his opponent, or drugged up. There are too many well-documented stories of people being hit is seemingly critical spots with multiple .45 or .357 Magnum rounds who continue the fight. As best I can tell from various documents about wounds damage and related ballistics, truly damaging temporary or permanent would cavities occur most often with rifle rounds, or very high velocity handgun rounds -- and the 5.7 seems to fall into that category.