I'm sure what this thread needs is another vote, so I'll say the XD45 5" Tactical. A handful of pistol that looks as good as it shoots. So many choices out there for this caliber, but for each of us, usually one stands out. Next to my GP100, this is my favorite handgun.
Sig P227 Tactical. All-inclusive, large polymer 45. Accurate, amazingly tiny recoil, raised night sights, rail, large capacity mags (although larger mag should contour into grip like an XD for better looks), threaded barrel, ergo comfort, etc. I dig my others 45 polymers but this one is atop the heap.