My favorite polymer defense pistols are:
M&P40
P320 40 Full Size
M&P40C
Glocks are ok pistols, but my preferred defense caliber is .40S&W. And Glock forties are comparatively harsh-shooting.
The M&P40, P320 40, PPQ 40, and VP40 are all very soft-shooting and quite enjoyable to shoot, as compared to the G23, G27, and G22.