For me, a combination of de-escalation, followed by a fast exit of the area has always worked. I imagine however, that in the face of someone determined to do you harm almost any style will be effective. Fear of bodily harm tends to make one move faster than the average Joe would expect. On the other hand, an in-depth knowledge of a versatile close combat system such as akido would probably have advantages. You will be more confident in a confrontation, which could help you talk your way out of the fight, and if it actually comes down to doing ugly things to each other, you'll know some good dirty tricks to play. Before all though, use your Nikes before your fists. Then you don't need an ambulance or a lawyer.