My opinion on this matter is that you need a good weight/speed ratio. IMO, 115 grains at 1400 FPS (really hot 9mm) is marginal for self defense, 135gr .40SW at 1300 FPS, and the 165gr .45 at 1250 fps are better. I believe in the theory of hydrostatic shock, but I don't believe that it damages nearby organs such as the lungs, liver, kidney, etc. I believe the effectiveness of a handgun cartridge spikes when it travels around the 1200-1300 fps mark, because the hydrostatic shock provides just enough wallop to the nervous system with good shot placement, and causes it to fail for a small amount of time, making the BG drop. Rapid blood loss means a rapid drop in blood pressure, and I think the knockdown from the initial hydrostatic shock to the nervous system is just enough to keep the BG down for the effects of blood loss to take its place. Nobody in fear of their life if going to fire one round, and getting up after losing a few pints of blood and a "walloped" nervous system must take a lot of practice, regardless if he feels the pain or not, don't you think?
Edit.
Brassfetcher
Federal .45 ACP 165 grain hollow points at 900 feet per second penetrated 10-14 inches of ballistic gelatin with 0.75 expansion, with a 3.8" barrel. Given, Humans are not gel, but it gives a rough estimation of how much penetration would occur. Hit the sternum, and you will get less penetration. However, Corbons .45 ACP 165gr HP's at 1250 FPS will have adequate penetration, and enough velocity to create a large temporary cavity, and have a large permanent cavity. Its not like you have to pick either or, you just have to look for the right loads. You don't need extremely heavy bullets to properly penetrate, just a good mixture of velocity and bullet weight.
.355 bullet diameters at high speeds are effective, but with the .451 (1250fps) you have a wider diameter bullet displacing more tissue than the former, smaller round. Thought for the brain, I guess?