I'll start by saying I didn't read all the posts in this thread, so what I'm saying might have already been said, but this is my view on it.
Overall, I am going to vote yes, it MIGHT make a difference.
Starting with general carry, especially with open carry, I don't want a flashy gun that will draw alot of attention. I normally carry my PT940; it happens to be the model with the gold accents and pearl grips. Unless I'm going to the range, the pearl grips stay in the box and the gun wears standard black rubber grips.
In a legal situation where a jury is involved, I can see maybe some jury members being slightly influenced by the color/appearance of the gun. Some people may view an all-black handgun as scary or intimidating, while maybe a little revolver with pink grips comes across "softer," perhaps even "cute."
This will obviously vary with the demographic; I don't think there is a right or wrong answer to this question.