I have a rack that hangs on the door of my safe, and holds 8 handguns, muzzle down.
I'm keeping my HK P7 PSP in the left most slot (facing the rack). I'm left handed, so that works out well.
I do have loaded handguns elsewhere in the house.
As a visual reminder that that handgun is loaded and a round chambered, I've taken a fluorescent orange target dot and put it on the magazine base. It's immediately visible when I open the door to the safe.