well that depends on alot of things. 99.9% of the time its no you CAN NOT draw or shoot over a fist fight. There is a few situations depending on the state you are in. For example Ky. where I live, gives you the right to use deadly force if you have reasonable fear you will be raped as long as the attacker has the means and you beleive they have the intent to do so. Also you have the right to use deadly force if you are in fear of being maimed or are at risk of serious personal injury eg...... beaten into a comma, loss of limb ect. There is no mention of the attacker having to be armed in those situations. However if its a fist fight and nothing more do you want to go to bed at night knowing you almost shot some one or worse you did shoot some one over a common brawl. And if you did draw what bed would you sleep in that night yours or the county jail's? I'd say learn to fight without a gun you can allways have the gun as a LAST resort to protect your life not your pride.