The AR15 had been developed into a mechanically reliable system. If you are using quality, brand name, brass cased ammunition, using Colt magazines (I have experienced issues with Military 30 round magazines), kept your AR well lubricated, you should be able to fire thousands of rounds without a jam.
A bud of mine worked on the rebuild lines at Annistion Army Depot. They would pull a rifle from a lot of rebuilt rifles and shoot the thing 6000 rounds. They would shoot 6000 rounds as fast as they could, blowing compressed air in the chamber and up the barrel between magazine changes.
He could not think of a single time that a rebuilt M16 malfunctioned.
This is not to say that M16's/AR15 are not dust sensitive, they are, and they have to be kept clean and lubricated for best performance.
Any semi - fully automatic mechanism will gum up given enough ammunition. Breech friction will always defeat a self loader.
There are less dust sensitive designs and there are designs that have more rugged magazines.
From what I have seen and read, AR's are sensitive to case material. You read all the time about jams with steel cased ammunition. I believe this is due to the fact the .223 round was created by a "couple of guys" at Bob Hutton's ranch in the 50's, it is a wild cat round, and they did not spend time or money looking at different materials, tapers, case to chamber tolerances, case hardeness, etc. They just got a round that went a certain velocity with a small bullet. The round was not developed as were the 7.62 X 39 or the current Chinese rounds.