I voted yes, the first handgun I fired much was a .22LR. Grampy's High Standard as I recall.
Ironically, the first handgun I bought was a .44 Magnum. But I had a parade of other firearms I was allowed access to on a regular basis well before then; 9mms, .45s, .22LRs, a couple of other .44s, .357s.
Honestly, I cringe sometimes watching new shooters trying to learn with major calibers and lightweight poly frames, etc. While some can learn to shoot passably well, most of what I see on the range makes me think that's a small minority. A little time with good instruction and a quality .22LR can make a world of difference.