Everyone has their favorites - makes, styles and calibers.
I own a number of handguns - more than I need!
I have shot SA for 50 some years and right now, besides C & B, my "cowboy" guns include -
Uberti Cattleman 7 1/2" 45 Colt
Uberti Bisley - 4 3/4" .357
Ruger New Vaquero - 5 1/2" .357
I only shoot reloads - smokeless & BP - and only cast bullets that I cast from a variety of molds.
All that I have are excellent revolvers and well made. If I had to put them in order of preference, it would be as I've listed them above. I love the 45 Colt - the Uberti is accurate and fun to shoot - but,if you don't reload, then the cost of ammo can get to you.
The Bisley is an excellent shooter as well and mine eats a lot of 38 specials and I even reload 38 Colt Long and 38 Colt Short for it as well.
I like the Ruger NV but I really need to have the cylinder throats reamed larger. Ruger is notorious for undersized throats which are under bore size. A competent smith can take care of that though.
The throats on my Uberitis were just fine when from the factory. Example - my Uberti 45 Colt has a bore size of .452 and the throats are just about right on .454. I use the traditional 255 grain RPFN cast bullet and it drops with my alloy at right around .453 - .454 so I just shoot them unsized and tumble lubed for smokeless and finger lube them for BP with BP lube. I ran across a box of 500 commercial cast 255 gr RNFP that were .452 and they shoot just as accurately as my slightly oversize cast do. No problems with either as far as bore leading.
Pick what you like in the caliber and barrel length you like and then don't second guess yourself - you'll enjoy whatever you get. If I could only have one, it would be my 7 1/2" 45 Colt as I like to play with it at 50 yards and the longer barrel and sight picture works better for me. My next one will be with a 4 3/4" barrel though as it will be an easier carry on walks, etc. on the farm and for just fun plinking at shorter ranges. Good luck and enjoy!