Until the last month or two, I carried a 10mm full-size, all-steel 1911, during all my waking hours, in a homemade under-the-shirt vertical shoulder holster. Concealment and comfort were both near-perfect. Then, after a close, eye-to-eye encounter with a mama black bear and her two cubs, I bought a S&W69 (.44mag 5-shot 4-1/4" L-Frame). I was surprised, and delighted, that I could conceal-carry it in a similar holster, just as well as the 1911. And it continues to work well, even after I replaced the stock grip with the slightly larger "500" grip (the stock grip for the S&W500 X-Frame).
[Addendum]
I should add that there is one thing about my carry method that might be a "show-stopper" for many (maybe most(?)) people: disguising the slight bulge (due to the grip butt) just at the outside edge of my left shirt pocket requires that I carry a lot of stuff in that pocket. For me, that is a "zero-cost" item, because I carried all that stuff in that pocket long before I started carrying in an under-the-shirt shoulder holster.
[End Addendum]