That right there is what's called the scientific method of inquiry, but it is not at all appropriate in this situation.
In a laboratory, nobody cares if that gun vanishes in a cloud of shrapnel. Right now, he's doing his research on a very up close and personal level. Changing primers, brass, crimp, cleaning chamber, whatever, changing one variable and then the other is not the way to do it. Changing the wrong variable can be lethal.
I believe that someone mentioned changing brass, charge, and performing a number of other tests as well. Don't piddle around trying one thing at a time, when several of them are possible, even probable causes. Eliminate as many possible causes of that case failure that you can think of.
In a case like this, determining exactly what caused the failure may not be possible and the important thing is to just avoid another failure.