I usually carry something. What I'm hunting, where I'm hunting, what firearms are legal, how much weight I want to deal with, and which holsters I remember to bring factor into what I choose to carry. Sometimes it's a Browning Buckmark. Sometimes it's a Ruger P95. Sometimes it's one of my .327s. For most big game hunts, it's my Super Blackhawk.
Sometimes I carry to bag dinner. Sometimes I carry as a close-range or coup de grâce option. Sometimes I carry for 2-legged and 4-legged predators.
During big game hunts, I cannot carry the .22, even if I want to. They are prohibited on the "temporary game preserves" that exist any time a big game hunt is going on. And, depending on the state I'm hunting in, and the animal I'm pursuing, I may not be able to carry the .327s, 9mm, or even a .357, either.