If you want a bullet to punch through a shoulder, stay together and keep its weight, and continue going mostly in the same direction in one piece I've been very pleased with Nosler Parititons and Speer Grand Slams over the years. I don't shoot 243, but they have performed well in 30-06 and 7mm Rem mag. Enough so, that I haven't tried anything new like the TTSX people rave about.
Factory bullets usually do the job, but until you've compared them over a range of useage, you don't really notice where they don't perform as well. When they bust through the shoulder and fragment, they usually make for a quick kill on deer but I prfer the bullet stay intact, and bust though the other shoulder on the way out, especially on stuff a little tougher than deer.