All of those cartridges limit you to fairly large sidearms.
Revolvers that shoot .454 are VERY large. Unless it's meant to be a "bedside" gun, it's pretty much at its best as a hunting pistol. If it was loaded with milder rounds like factory .45 Colt, it would deliver a SUPERB balance between stopping power and controlability. It's just that their weight can be a detriment to portability.
A 4" barreled S&W M29 or similar piece would make a superb revolver for a fight, as any .44 Mag will chamber and fire the milder .44 Special round, which gives up very little in the way of stopping power. If you frequent areas where bear or large feral animals are encountered, stepping up to the magnum loads enhances your odds of ending an attack from them.
Currently, S&W makes a 5-shot revolver on their L-Frame (Model # escapes me), which would be a better compromise between power and portability, especially with .44 Special rounds. Expect it to be a major handful with magnum-level loads.
The 10mm is an excellent combination of stopping power, portability, and controllability, offering an easy platform to learn, carry and maintain, 10 or more rather powerful rounds quickly delivered, better controllability with full-power loads than the two revolvers mentioned, and a much faster reload than the revolvers mentioned.
Of the three calibers you mention, I'D probably go with the 10mm. If you are in a fight with one or more "two-legged predators", you'll want all the odds on your side that you can muster. A well set-up 10mm auto can deliver that.