You're never going to get a satisfactory answer to this question because there isn't even a consensus on what makes a given caliber effective or ineffective, much less which one is most or least effective.
Clearly we CAN get a satisfactory answer to this question (unless you are a black and white thinker and a dedicated perfectionist").
The question was posed as "Best Caliber for Self Defense."
Note that it doesn't say "most deadly" or "most cost-effective" or "most accurate" or "most shootable."
None of these details are included........it just has to be the best on average over a wide spectrum of conditions.
So, it's not a black and white issue, but one where the shades of gray must all be considered and a reasonable and practical conclusion reached.
Thus the obvious answer is a round that works best for a wide variety of people and is cost-effective, reasonably accurate, has sufficient power and is widely available off the shelf and in a good variety of handguns that make it convenient to carry (either concealed or on duty).
It helps to reach this decision if this round is now gradually being adopted by the majority of law enforcement agencies because they favor it over the failed .40 S&W that was once thought to be the best all around choice for armed combat.
The clear and satisfactory answer is the 9mm Parabellum.
Parabellum' is Latin. It's the second half of a Latin phrase. 'Si vis pacem, para bellum.' It's basically, If you want peace, then [prepare for] war. So, parabellum can be interpreted as "prepare for war."
Aptly named. And many view it that way, for it is the most widely used wartime pistol cartridge in the history of the world.
I say this in full awareness that there are many recalcitrants like myself who will obstinately choose the .45 ACP or even the .22 LR as best (for them).
That is neither here nor there and not pertinent to the question posed by this thread.