Aluminum does fatigue more easily than steel - that's easy to verify with a little googling.
But that doesn't mean that aluminum framed semis are done that way to cut corners. It will save weight, I'd take a guess of 1/4lb+ on a full size semiauto. For a nightstand, hunting or target gun, the extra weight is an advantage - holds sights steadier and is more controlled and comfortable in recoil. But for a carry gun, it's a disadvantage.
Under normal use, the aluminum frame will hold up, and owners will appreciate the weight savings in a carry gun. That's called an engineering tradeoff, not cutting corners.