If you're going to be a GUN GUY, there are two you've got to have, both from Colt: a 1911 in .45ACP and an AR-15. Fact: Sooner or later, you have to have both of them. So, you can start now with the 1911, and there's your caliber decision.
OTOH, if you are a practical thinking concealed and home protection guy, you need to look at this real world study of 1,800 actual shootings that found that, regardless of caliber, 2-3 hits were on average required to stop an adversary.
http://www.buckeyefirearms.org/handgun-stopping-power
If the typical street robbery or home invasion is three perps, and you miss one of three shots, then you need 3-4 shots per perp X 3 perps, or 9-12 rounds minimum on tap (forget reloading; that's when you get killed). So whatever you decide, be sure it holds enough ammo.
Also worthy of note. It seems the law enforcement agencies that years ago abandoned the 9mm for the .40 or .357Sig, are moving back to 9. Improvements in defensive ammo is the usual cited reason, with ability to carry more ammo at a lower cost, usually added as another consideration.
Three years ago I sold my last 9mm, a Glock 19, and went all 45acp. A Colt XSE (8+1 rds), Springfield Armory XDM-45 4.5" (13+1), and then last year, a Sig P227 (10+1 or 14+1)--my Deluxe handgun. Then in March, I won a Glock 19 in a drawing I didn't even know I had entered. Since the price was right, I sprung for a Cominolli thumb safety and TruGlo TFX combo tritium/fiber sights, and I like that "improved" G19 so much (15+1 rd), I've re-adopted it as my carry pistol. I still like shooting a .45, but that G19 is the ultimate all-purpose carry/home pistol, and now that 9mm is back in fashion...
Other calibers. [Personal opinions here] The .357Sig has extraordinary ballistics, but I've found it just too darned loud and painful to shoot much. Also expensive and usually with not much of a selection of ammo types. Those characteristics make it a practice inhibitor, and that's bad. The .40 has been a popular compromise between 10mm (which female FBI agents couldn't handle; and the .40 was designed for them) and the 9mm. Always a good choice, but not IMO for a small gun, as I don't like the hard muzzle rise. Also more expensive than 9mm.
The .45acp is the all-American round. When you say, "I carry a .45", people know you are serious and dangerous.
OTOH, if they know much, they also know that a .45 in a big handgun like a 1911 is really a joy to shoot. Moderate recoil and nice big Texas-sized bullets. I personally really like the .45acp. It's also not cheap to shoot, but reasonable. Often cheaper than .40 and almost always cheaper than .357Sig.
Bottom line. You don't have to store as much ammo, if you have just one caliber. That was my .45 rationale. Three rounds: .45acp, 5.56mm, and 20-gauge. Now I have four, and I'm really enjoying shooting the economical 9mm again, even if it has increased my inventory levels.