Drag, I guess it depends on your sighting in comfort level. At any distance, I want my point of impact (POI) aligned with the front sight, ie. no windage or deflection to either side. Admittedly, this will vary whether I'm shooting one-handed or using both as God and Col. Cooper intended. The beauty of adj. sights is the ability to get that windage in without major frame or front sight machining.
My NV in .45 LC shot two inches low and left with my standard load at 25 yds. Closer in, at 10 yds, it was still an inch low and left; ie. more than I wanted. I ended up widening the rear notch on the right side, nearly .020" to center the impact point as to windage. I also lowered the front sight by judicious use of a fine mill file to get the elevation right.
It worked for me, but is a PITA...believe me when I say that I spent some anxious minutes with a thoroughly taped up revolver in my padded vise while filing. The procedure was file a little, measure with a mic, then shoot several groups, then back to the file work. In the end, I got what I wanted, but getting Ruger Inc. to turn the barrel a mite, would have been a better solution were they willing to do that.
Like you, I like the way that slick NV rides in a Tom Threepersons open top holster...no adj. sight wings to catch on clothing etc. but sighting in to my druthers was a pain, and in all honesty, you get a better sight picture with a broad wing adj. rear sight blade than with any rounded frame notch.
Here's a pic of the rear end of that NV after filing and cold bluing. In use, I don't notice that it's offset to the right by that amount, but would opine that .020" is about the limit in that regard.
Best Regards, Rod