Well, I'm bound to step on some toes here, hope I don't stomp too hard.
Some people think that if you carry a round that will overpenetrate that you WILL hit some innocent person. Not true. Your chances are very slight of this happening, even in the tighter parts of a city. I've spoken to numerous state police, sheriff's deputies, attourney general, and an attourney about this. None had even heard of it happening in FL. That's not to say it hasn't happened, just that there's a lot fo hand-wringing and passing on of second and third hand stories.
IMHO, if you're that worried abotu overpenetration, carry a knife and leave the guns at home. Overpenetration MIGHT hurt someone else, underpenetration (a bad habit of these superlight & fast bullets everyone just HAS to have) can kill YOU. At least the knife can get to the vitals. The only time I've been in a situation to need a gun where someone else might have been at risk was an attempted carjacking. Had the goon made me shoot him, instead of running at the sight of the stainless steel cannon, the bullet WOULD have gone right through his head and landed somewhere else. BUT, the same would have happened even if I was carrying a .380.
The biggest problem would be the noise if fired inside a house or vehicle. 'Course I guess better deaf than dead. Wear soem electronic hearing protection in your house if you think trouble's about, even if you're using a .38 or 9mm. Both are screaming loud indoors.
That being said, I often carry an S&W 629, 4". I load the 240-gr Hydra-Shoks, and they ARE self-defense bullets. I get just under 1100 fps out of the 4" tube. To me, it sodesn't kick any harder than .357 Magnums out of my SP-101. So if you can handle a steel .357 snubbie, you can handle a .44 Magnum.
So to answer the original question, IF you can hit with the .44 magnum, and IF you are comfortable with the recovery time, or are willing to develop the skillset necessary, then by all means, carry one.