I have a Ruger .44 mag that used to be my 1st line HD piece that has been replaced with a 1911. At the time, it was a double duty piece: hunting arm and HD.
Why? Economics, safety and common sense.
1) When you touch off that .44, . . . every window in that room will shatter from the concussion as well as dresser mirrors, etc. leaving you in a room with broken glass all over and in all liklihood, . . . barefooted.
2) You will suffer some permanent hearing damage, . . . directly proportional to the number of rounds you uncork.
3) You will risk everything and anything behind the bg as penetrated, broken, shattered, bloodied, whatever: even if you hit the bg.
Any cartridge from a .38 special up to a .45 ACP, including 9mm, 10mm, and even .40 are better choices for HD than a .44 mag.
The best argument, though, is the aftermath: the bg's attorney, or the local prosecutor looking to make a name, or the bg's widow's attorney will paint you as a neanderthall war monger who just sat night after night on the end of the bed awaiting someone to break in so you could do him in, . . . Dirty Harry style with a S&W 29. It really isn't worth the risk.
Downsize that hand cannon to something more akin to what the LEO's in your area carry and pray you never have to use it.
May God bless,
Dwight