The ability of the 6PPC/.220 Russian case to take the pressure isn't the problem with getting additional velocity - The problem lies in that if you keep upping the pressure, you need a stronger locking bolt, receiver, etc. I think that someone calculated that the average Remington bolt is good for about 200,000 PSI, but the rule of thumb is that you should have a minimum of 3X the "theoretical" strength needed, to ensure that you don't end up wearing the bolt in your face.
And that pressure issue will be the same with any round...
Personally, I like the idea of the average grunt being able to carry a bleepload of ammo. .22 Hornet (actually, I'd go with a thicker case version) would be fine - The grunts don't aim half the time anyway, so give 'em something to spray and pray with... A 30 grain bullet moving out at over 4,000 fps (and I've got a 55 grain Nosler up to 4,000 fps in the 6PPC and 4,100 fps in the 6BR, but I don't recommend that for everyone...) is something that you don't wanna be on the receiving end of... Even at 2,500 fps, you've got something very nasty, with little recoil, out to a couple of hundred yards... Heck, should we ever get into a conflict where we have to deal with the "human wave" thing again, I'd like to see us have .22LR miniguns - Lots of ammo available per resupply, and with 6,000 rpm firepower - what does 6,000 rounds of .223 weigh vs. 6,000 rounds of .22LR? You can saturate an area, and the relatively wimpy cartridge doesn't matter - ever shoot a full auto American 180? They'll chew through a cinder block in no time flat...
FWIW, it'd be interesting to replace the concept of the .308 cartridge for the "battle rifle" with a high ballistic coefficient 6.5/284 cartridge, like those little girls have been using to whip butt with up at Perry...