I have a Savage over/under. It's a .22 on the top barrel, and a 20 gauge on the lower barrel..Have taken more game with it than any other gun I own.
I discovered that the 12 guage if I didn't let the birds, rabbits, etc. get out aways, it would tear up the meat...since I'm not interested in shooting clays, but was more concerned about putting food on the table, this gun did it all!
I got brass shells, reloaded and developed a nice mild load which got the job done, but left "something" to eat!
If the little critter were mo-tating out of the country, the shotgun did its job, if the little critter stopped to see where I was, the .22 through the head did it's job...