I've had two Rem 700, .22-250s, but didn't shoot them much at the range, only enough to make sure loads were shooting well and to check sighting-in. Then it was off to the chuck fields or turkey shoots. I never wore out a barrel, but my first one didn't get cleaned after woodchuck season one year and it got pitted. I almost cried when I looked through the bore, after finally cleaning it. I never leave my CF bores dirty since that day.
IMHO, the .22-250 is not a cartridge to shoot hundreds or thousands of rounds at targets. I think of it more like a super drag car that may only run a few miles, but does so exceedingly fast. Why burn a car like out driving to the store to buy beer?
The cartridge does very well at varmint hunting due to velocity, but The .223 Rem or .308 Win are much better range cartridges, loaded lightly for accuracy and long barrel life. My turkey shoot loads were very mild, but we rarely shot more than 10 shots a day at those matches, so barrels lasted about forever.