All of my handguns are in my sig. I can say that I love all but one of them at this point. I like my Gen 4 Glock 17, but I can't say I love it. I think it's a very good gun, but it seems sort of soulless to me at this point. Maybe I'll grow to love it with a few more trips to the range.
My favorite semi-auto is easily my first Beretta 92FS. I love my P229, Hi-Power, and so on, but nothing gets my semi-auto shooting passions stirred like my Beretta. I'm crazy about my new INOX, too, but it hasn't been around long enough to pull even with my older 92FS.
My current favorite revolver is a blued S&W Model 57 (no dash) with an 8 3/8" barrel. A few months ago it was my Python. They'll probably trade places again. My Freedom Arms Model 83 is the finest handgun I own, but I don't shoot it enough to have the same affection for it that I do for these two other revolvers.