WHY?
THE WAY I SEE IT: If you don't already have a large-bore revolver, before you go out and buy your first one, you should think hard about what you want it for. If you can afford more than one, your first one should be the one that best fulfills the criteria of being the only one you can have, the one you would use a lot. Like those guys here that have a collection that they actually use: Make them throw away all their handguns forever but one; which one would they keep. Everyone has their own reasons for having one. Mine is primarily for backwoods wilderness hiking, camping, fishing,etc., deep in bear country. I want a balance of plenty of power, controllable recoil, as mild muzzle blast as can be reasonably attainable in case I ever have to use it without hearing protection. My choice is Ruger's original Vaquero in 45 Colt. And yes, it's the only one I have. A good second choice in calibers for me is 44 Magnum; since I reload I can make either one do what I want. Both cartridges can do the same job but the 45 Colt will do it at less pressure/muzzle blast. For me, 255 grain bullets between 850 and 1200 fps is all I want. The fixed sights never change. Works for me.