So far, I've been very much impressed by handloaded Hornady GMX bullets in 30-06, .270 Win, and .243 Win. One-shot kills, good pass-throughs and great internal damage.
Regarding lots of blood, I've seen high lung hits that didn't produce a great trail, especially at 200 yards or more, regardless of cartridge. Often deer blow small drops out after 15-20 yards, but the deer often dies within 30 yards. Lower lung hits that don't destroy the heart cause much more bleeding, since the heart pumps it to blown-out lungs and exits through the lower holes. The deer may run a bit farther, or not, depending on whether the lungs work reasonably well.
Heart-shot deer tend to run 80-100 yards, regardless of bullet used, and may or may not bleed a lot, but usually enough to track easily.
My favorite side shot is over the front leg, but not as high as the shoulder. It's the biggest lung area and close enough to the heart to often cause a ruptured aorta. They never seem to go more than 25 yards and bleed out quickly.