45gr has less penetration than is ideal, but if I remember correctly, quite a few SWAT teams back in the late ‘80s/early 90s used a Federal Blitz 40gr load, probably out of 1:12 barrels, that was apparently fairly highly regarded at the time (I remember Marshall and Sanow cited a lot of LE shootings with it). The science of terminal ballistics has moved on quite a bit since then, but I would imagine that 45gr might be decently effective for perpendicular shots without intervening limbs. But there are certainly more reliable choices for the edge cases of an intervening muscular arm or an oblique angle.
My current HD load is Winchester 55gr SP, FWIW.