I have a Sig P226 and a P239. Great guns!!! I bought the P226 almost 30 years ago. I was debating the HiPower or the Sig, until I held them. The Sig fit my hand just right. In the 30 years of shooting it, I haven't had a jam or failure-to-fire that was not ammo related (I had a bad run of reloads). Every factory ammo I've shot in it has resulted in reasonable accuracy and excellent reliability. When I got my CHL a couple of years ago, I bought the P239 since it is easier to conceal. It doesn't fit my hand as well, but I trust it, and it functions the same as the P226 that I've become so familiar with.
However, there are other great guns out there. A friend recently said he wants to buy a full-size 9mm for home protection, and asked me what I'd recommend. He's experienced with revolvers, but this will be his first semi-auto. I told him that he should go to a good gun shop and hold (and fire if possible) a Sig, Berretta, Glock, HiPower, H&K, etc. and buy the one that feels best to him. Of course, I gave him my personal preference for the Sig, and told him that there are several other good manufacturers, but he can't go wrong with these main ones.