My experience is limited to 1911's, Berettas (92FS), Walthers, Rugers and Glocks. The only calibers that I have fired extensively (more than 5000 rounds) are the 9mm, the .40 S&W and the .45ACP.
Based on the foregoing, and on the fact that I place a relatively high value on my life and on that of my family, the following list reflects MY ranking of the self-defense handguns that I own. This ranking is based on out-of-the-box RELIABILITY:
1. Glock 21 (.45ACP - 13 rounds +1)
2. Glock 23 (.40 S&W - 13 rounds +1)
3. Glock 27 (.40 S&W - 10 rounds +1)
4. Glock 17 (9mm - 17 rounds +1)
5. Glock 19 (9mm - 15 rounds +1)
6. Beretta 92FS (9mm- 15 rounds +1)
7. Colt 1911 (.45ACP - 7 rounds +1)
FOOTNOTE "A" : Before the flames start, I have omitted the Sigs and Hk's ONLY because I'm not personally familiar with them. I am certain that they are reliable and accurate, I just haven't owned either, and thus haven't fired either extensively.
FOOTNOTE "B" : My ranking is not based on which pistol is the prettiest, the most expensive, has the oldest design, has the best sights, etc, etc, etc. It is based on my experience in shooting JHP self defense ammo (Hydra Shock, Golden Saber, Gold Dot, etc) WITHOUT A HICCUP.