My wife's not a member of TFL, so I'll answer ... my nightstand gun for years has been a Springfield Loaded 1911. It kind of won the slot by default because it's the only gun I own with night sights, but I love shooting it and it's very accurate at household distances.
I'm one of those folks who has guns in a few other rooms as well, mostly revolvers, but the 1911 is my go-to gun if the beagle starts barking at 2am.