12 gauge is primary, but there is an HK45 handy if searching the house is needed. Fits my X300, has 10+1 of .45ACP, and I prefer a "cocked and locked" or condition one gun for this purpose.
When someone makes a good striker-fired .45ACP with the European-style mag release, I might consider changing, but the HK45 is not going anywhere. This would probably be the VP45, since Walther doesn't seem to be committed to the .45, though maybe that will change as they get established in America.
I have a 10 round limitation in my state, otherwise this would be a PPQ or VP9 for sure. However, if we're doing wishful thinking, if I lived in a truly free state I would keep the .45 and have a dedicated suppressor on it for home use.