The Paterson certainly broke new ground. Prior to 1836, the only idea for revolving chambers had been the "pepperbox" types.
While the Paterson had its weaknesses, the next effort, the Whitneyville Walker model certainly formed the mold. Not until the .44 Magnum was produced, was there a more powerful handgun. All Colt revolvers after that, were variations and improvements on the Walker.
Rollin White's patent, and subsequent sale to Smith & Wesson, put them in the driver's seat until 1873. S&W was far more successful in Russia, Japan, and Turkey, than in the U.S. with its 3rd Model. It was a huge success, and provided the capital for S&W to get to a double action design. However, Colt, with their late 1800's invention of the swing-open cylinder revolver, is probably the clear winner of a revolver that changed everything. The break-tops were generally weak because of the barrel/cylinder pivot point. And S&W boldly copied Colt's design.
So, the revolver that changed everything is the Colt Model of 1889, Navy revolver, which was the first swing-out cylinder. It completely changed the game, and led to the Python, the Model 29, the S&W .357 Magnum.