There are a lot more aftermarket accessories for the Ruger semi-autos- that is for sure.
I have the original Ruger 22/45.
I had to change the trigger, trigger bar, sear and hammer bushing to get my Ruger to have a trigger as good as my Buckmark Nickle Plus out of the box.
I changed my Buckmark Nickle Plus's trigger to the [discontinued] Browning-made trigger with overstop. Now my Buckmark is, again, better than my Rugers- with $150+ in parts.
If you don't like the grips on the Ruger, you can look into changing the entire grip frame. It is NOT the receiver/serialized part. Volquartsen makes replacements. You could find a MK III slanted frame as a take-off if you prefer that angle.
HOWEVER, changing frame may require modification of the barrel/receiver 'tongue' notch that locks into the gripframe.
Become a member of rimfire central dot com. There are a LOT of tuning tips over there.
IF you ever go Buckmark route, they are a tried/true design. Yes, some parts are under the grip panel- where unburned gun powder doesn't get into the action and gum it up. This is where Beretta's, Walther P38 and other designs also route the parts. My High Standards have the parts under the grip panel also.
All it takes is attention when removing the panels to not lose parts.
As for buckmarks- I bought the Tactical Solutions Trail Lite integrated scope base and rear sight. Now, I can do reddot or iron sights.
I also had Bill Striplin install his Buckmark Slide Racker- to make it easier to use. Not as good for holster, but I have other stuff for holsters. Here is what it looks like-
This take away some of the issues with gripping the slide.
I like having one of both, but I don't need both.
If I were to have only one option for 22 semi-auto, I don't know if it would be the buckmark or the Ruger MK II Government Target [with the 6 7/8" barrel].
If it were a choice between a 5.5" barreled [or shorter] Ruger or the Buckmark, I'd probably go with the Buckmark.