S&W 22 was too fat for my medium-smallish hands.
No Neos experience.
Ruger MKII vs 22/45: a toss up. I like the grip angle of the 22/45 better, but they are about equally reliable. Whichever fits your hand better and points more accurately is what I would get.
BUCKMARKs are underrated!
Trigger out of box on Buckmark puts the Rugers to shame. I had to throw in a Volquartsen Sear and a Clark hammer bushing to get the Ruger as smooth as the Buckmark was out of the box.
I have a buckmark with a spring modification and a Browning adjustable trigger [$35 in parts] and it is decidedly crisper, lighter and smoother than any of my Rugers. HOWEVER, it now requires so little trigger motion that I wouldn't holster-carry it. This is now one for the shooting range only, and people more experienced with firearms.
For field use, don't change the trigger on the Browning Buckmark Camper, just change out the spring, and you will have a gun that is on a par with the Rugers accuracy and reliability, but with a better trigger. Plus, the basic cleaning is simpler, as it has a slide that locks back and allows a nylon brush across the face of the chamber and bolt, with gasses and debris escaping on both sides, instead of the single opening on the Ruger. Also, the trigger bar that activates the sear runs outside the frame [like High Standards, Walther P-38, Beretta 92, and (I think) colt woodsman]. This means the Buckmarks trigger doesn't 'gunk up' like my Rugers do.
I am NOT saying that the Buckmark is a completely superior pistol to the Ruger. I like the Ruger enough that I have more of them than Buckmarks. However, The buckmark has some great characteristics that deserve your attention.
I wouldn't turn my nose up at another Buckmark [or Ruger MK II].
MK III basically is a MK II with takedown complications and potential jamming points due to LCI and mag disconnect [the last two of which can be bypassed].
Stick to bull-barrels.
Good luck!