If I wanted a new 45 that wasn't a 1911..
I think I'd look at the Sig, and the CZ 97.
The Glock 21 is just too big of a gun for me, and the Glock series.. (brand me for it) but without the "NY Trigger" I wouldn't want to carrya glock as a ccw.
Sigs have a great track record of reliability, and they point naturally. Just for the price i'd take a long look at the CZ.. the reliability and toughness of the CZ is well known in eastern europe and for a while the CZ75 was the 'bees knees' of the shooting community. It would definitely get a once over from me.
Ruger makes a good gun.They work. They are Ugly they are oversized. They are too bulky for ccw (to me). they are inexpensive and robust and durable.
You did mention a house/target gun rather than a carry piece.. have you considered a para ordinance LDA? Its got the advantages of the 1911, slim light etc but its double action.