That can happen. Part of Newberry's thinking, though, is that if the Federal 168 grain Gold Medal Match load does well in most all rifles (and it does; not saying there are no exceptions, but it seems close to universally liked) there ought to be other combinations that work well in most rifles, too. He has a list of loads that he believes enough different people and guns have tried to fall into that category. Once you go outside those load combinations, though, you may or may not find a universal (or nearly universal) combination like that is possible and you may find your gun doesn't like much of anything you do with it.