There have been thousands of threads about the smallest suitable caliber for self-defense, if the .380 is enough, can a .357 stop a grizzly, etc. However, I can't remember a thread about the largest caliber you are willing to carry for self defense, so lets do it.
Break it down into two categories, largest for self defense against humans, and largest for self defense against wild animals (moose, bears, cougars, etc).
For me
Human self defense - .40 or .45 in an auto, .38 +p or .357 for revolver. Anything bigger than that and I feel you give up too much in terms of pistol size, recoil, and rate of fire. (Sorry 10mm fans )
Animal self defense - .44 magnum. I've shot .454's, .460's, and .500's and for each of those I almost get off 2 shots of .44 mag to every one shot I can get off with those calibers. If I have a moose or a grizzly charging me, I"d rather get two shots with a powerful caliber, than 1 shot of a uber powerful caliber.
Break it down into two categories, largest for self defense against humans, and largest for self defense against wild animals (moose, bears, cougars, etc).
For me
Human self defense - .40 or .45 in an auto, .38 +p or .357 for revolver. Anything bigger than that and I feel you give up too much in terms of pistol size, recoil, and rate of fire. (Sorry 10mm fans )
Animal self defense - .44 magnum. I've shot .454's, .460's, and .500's and for each of those I almost get off 2 shots of .44 mag to every one shot I can get off with those calibers. If I have a moose or a grizzly charging me, I"d rather get two shots with a powerful caliber, than 1 shot of a uber powerful caliber.