My home defense load is my practice load, is my competition load: 4.6-4.7/Promo/225 Lee TC. I make it by the bucket-full and shoot it the same way. Once I'm through this 8lb jug of Promo, I may switch over to Unique, because I can use it in more calibers.
Early in my shooting career, I took to heart some advice from a very old, very wise man who was kind enough to bother to impart knowledge. He said, "Find one load that works for your pistol, I mean REALLY works for your pistol, and practice with it to the exclusion of all others. Shoot other loads in it for fun, if you must, but when shooting for keeps, use that one load that you've gotten to know so well."
JMO
